The DECIDE Project: Designing and Implementing a Prototype Service for Supporting Early Diagnosis of Alzheimer's Disease

This paper will present the design and implementation challenges of the innovative DECIDE service, to support research and early diagnosis of Alzheimer’s and other neurodegenerative diseases. DECIDE service, which is based on a Grid eInfrastructure, offers a set of tools providing quantitative measurements, to help researchers and clinicians make more informed diagnosis. As the service specifically targets the clinical community, it differs significantly from other initiatives since it needs to comply with the requirements imposed by the clinical routine in terms of accuracy, robustness, ease of use, data handling policies, adherence to clinical praxis. Moreover, sustainability aspects will also be discussed, since DECIDE aims to propose such service as a reference at European level, possibly extending it to other pathologies. We will then summarize the main results obtained to date, and the possible future developments

A specification for providing information about an end service to a Discovery Service (AARC-G063)

This specification defines how SP-IdP Proxies can provide hints about services towards Discovery Services to improve the user experience of the authentication process

Knockout mice reveal a role for protein tyrosine phosphatase H1 in cognition

<p>Abstract</p> <p>Background</p> <p>The present study has investigated the protein tyrosine phosphatase H1 (PTPH1) expression pattern in mouse brain and its impact on CNS functions.</p> <p>Methods</p> <p>We have previously described a PTPH1-KO mouse, generated by replacing the PTP catalytic and the PDZ domain with a LacZ neomycin cassette. PTPH1 expression pattern was evaluated by LacZ staining in the brain and PTPH1-KO and WT mice (n = 10 per gender per genotype) were also behaviorally tested for CNS functions.</p> <p>Results</p> <p>In CNS, PTPH1 is expressed during development and in adulthood and mainly localized in hippocampus, thalamus, cortex and cerebellum neurons. The behavioral tests performed on the PTPH1-KO mice showed an impact on working memory in male mice and an impaired learning performance at rotarod in females.</p> <p>Conclusion</p> <p>These results demonstrate for the first time a neuronal expression of PTPH1 and its functionality at the level of cognition.</p

Guidelines for expressing group membership and role information (AARC-G069)

Information about the groups a user is a member of is commonly used by relying parties in order to authorise user access to protected resources. This document provides guidelines for expressing group membership and role information across AARC BPA-compliant AAI services. Specifically, it defines a URN namespace for expressing this information using common identity federation protocols, namely SAML and OpenID Connect/OAuth2

Framing effects in intertemporal choice: A nudge experiment

This paper experimentally investigates the framing effects of intertemporal choice using two different elicitation modes, termed classical and penal. In the classical mode, participants are given the choice between receiving a certain amount of money, smaller and sooner, today and a higher amount, larger and later, delayed (e.g., “€55 today vs. €75 in 61 days”). This is referred to as the standard mode. In the penalty mode, the participant must give up an explicit amount of money in order to choose the smaller and sooner option (e.g., “€75 in 61 days vs. €55 today with a penalty of €20”). This is the explicit mode. We find that estimates of individual discount rates are lower in the explicit mode than in the standard mode. This result suggests that even very simple information about the amount of money one must surrender for choosing the earlier option increases delayed consumption. The finding has relevant implications for self-control and long-term planning in intertemporal choice

Framing effects in intertemporal choice: a nudge experiment

This paper experimentally investigates the framing effects of intertemporal choice using two different elicitation modes, termed classical and penal. In the classical mode, participants are given the choice between receiving a certain amount of money, smaller and sooner, today and a higher amount, larger and later, delayed (e.g., “€55 today vs. €75 in 61 days”). This is referred to as the standard mode. In the penalty mode, the participant must give up an explicit amount of money in order to choose the smaller and sooner option (e.g., “€75 in 61 days vs. €55 today with a penalty of €20”). This is the explicit mode. We find that estimates of individual discount rates are lower in the explicit mode than in the standard mode. This result suggests that even very simple information about the amount of money one must surrender for choosing the earlier option increases delayed consumption. The finding has relevant implications for self-control and long-term planning in intertemporal choice

Integrating EGI Check-in the Virtual Imaging Platform

International audienc

Integrating EGI Check-in the Virtual Imaging Platform

International audienc

Color and abundance: Influencing children’s food choices

Packaging color and product availability are factors influencing consumer preferences. However, their impact on children’s choices is scarce. The current research examines whether the size of the set of items and the packaging color might shape children’s choices. In three experiments (N = 887), we investigated the effect of these two variables on children’s choices of food items in a laboratory setting. The results showed that food items provided in larger piles of identical products were preferred to those provided in smaller piles of identical products, even though children could only choose one item to take away, showing evidence of an “abundance bias”. In addition, food products packaged in red were preferred to those packaged in green. A moderation effect was also observed whereby children preferred red-packaged items more when offered within a larger group of identical items (abundance) and less when offered within a smaller group of identical items. The findings provide insight into the psychology of color and abundance as choice attractors in children’s consumer preferences for food products